What are the Implications of ABCB1 Gene Polymorphisms?
Polymorphisms in the ABCB1 gene can lead to variations in P-glycoprotein expression and function, affecting individual responses to drugs. For instance, certain polymorphisms are associated with altered drug pharmacokinetics, leading to variability in drug efficacy and toxicity among individuals. Understanding these genetic variations is crucial for personalized medicine approaches, allowing for tailored drug therapies based on an individual's genetic makeup.
