Are There Any Therapeutic Strategies Targeting Amyloid Plaques?
Several therapeutic strategies aim to reduce amyloid plaque burden. These include:
1. β-Secretase Inhibitors: Prevent the initial cleavage of APP. 2. γ-Secretase Modulators: Alter the cleavage process to reduce amyloid-beta production. 3. Immunotherapy: Uses antibodies to target and clear amyloid-beta peptides. 4. Aggregation Inhibitors: Prevent amyloid-beta peptides from aggregating into plaques.
While some treatments have shown promise in preclinical studies, translating these findings into effective clinical therapies remains challenging.
