To overcome the challenges of implementing open science, toxicologists can adopt a few strategic approaches. Firstly, they can engage in education and training programs to better understand the principles and practices of open science. Institutions can foster an environment that rewards open science practices by incorporating them into performance evaluations and funding decisions. Collaborating with interdisciplinary teams can also provide new perspectives and resources. Finally, adopting clear licensing and data-sharing agreements can help protect intellectual property while promoting openness.