Mitigating the risks associated with man-made derivatives requires a multifaceted approach. First, it is essential to invest in green chemistry practices that aim to design safer chemicals and processes. Second, advancing analytical methods for detecting and quantifying synthetic chemicals in the environment can help monitor their presence and impact. Public education and awareness are also crucial, as informed consumers can demand safer products and practices. Lastly, international collaboration can help harmonize safety standards and share best practices for managing synthetic chemicals.