anthracyclines

How do Anthracyclines function?

Anthracyclines work by intercalating DNA strands, which disrupts the function of topoisomerase II, an enzyme crucial for DNA unwinding during replication. This interference results in the generation of DNA double-strand breaks, inhibiting cancer cell proliferation. Additionally, anthracyclines produce free radicals that further damage cellular components, enhancing their cytotoxic effects.

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