ADME processes can vary significantly between individuals due to genetic factors, age, gender, health status, and the presence of other substances (drug-drug interactions). For example, genetic polymorphisms in metabolic enzymes like Cytochrome P450 can lead to differences in metabolic rates, affecting both efficacy and toxicity. Age-related changes in organ function can also alter ADME characteristics, necessitating dose adjustments in pediatric and geriatric populations.
