What is the role of Pharmacogenomics in Anthracycline therapy?
Pharmacogenomics plays a pivotal role in personalizing anthracycline therapy. Genetic variations in drug-metabolizing enzymes and transporters can influence an individual's response and susceptibility to toxicities. For example, polymorphisms in the NADPH oxidase genes have been linked to increased risk of cardiotoxicity. Tailoring treatment based on genetic profiles holds promise for minimizing adverse effects.
