Toxicokinetics involves the absorption, distribution, metabolism, and excretion of toxicants. Aquaporins can influence each of these stages. They can affect the absorption of water-soluble toxins by regulating water flow across epithelial barriers. During distribution, aquaporins can modulate the movement of toxins through tissues by altering local water gradients. In terms of metabolism, aquaporins can impact the transport of metabolites and waste products, potentially influencing the duration and intensity of toxicant exposure. Finally, in the excretion phase, aquaporins in the kidneys play a significant role in the removal of toxins by regulating urine concentration.
