What is the role of PARP inhibitors in toxicology?
PARP inhibitors are drugs that block the activity of PARP enzymes, and they have gained attention for their potential therapeutic applications in oncology and toxicology. In cancer therapy, PARP inhibitors are used to exploit the concept of synthetic lethality, where cancer cells deficient in certain DNA repair pathways become highly reliant on PARP activity for survival. In toxicology, PARP inhibitors are being investigated for their ability to modulate the cellular response to DNA-damaging agents and reduce toxicity in non-cancerous tissues. This makes them promising candidates for mitigating the adverse effects of chemotherapy and radiation therapy.
