selective cox 2 inhibitors

How Do COX-2 Inhibitors Affect Cardiovascular Health?

The increased cardiovascular risk is believed to be due to the imbalance between prostacyclin (a vasodilator and inhibitor of platelet aggregation) and thromboxane (a vasoconstrictor and promoter of platelet aggregation). COX-2 inhibitors can disrupt this balance, leading to a pro-thrombotic state.

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