How Do Epigenetic Mechanisms Affect Toxicological Outcomes?
Epigenetics refers to modifications on DNA or histone proteins that regulate gene expression without altering the genetic code itself. In toxicology, epigenetic changes can be induced by exposure to environmental chemicals, leading to alterations in gene expression patterns that may result in adverse health outcomes. For example, DNA methylation and histone modification are two common epigenetic mechanisms that can be influenced by toxicants, potentially leading to diseases like cancer or developmental disorders.
