How Do Genetic Factors Influence Toxicant Metabolism?
Genetic polymorphisms can significantly affect an individual's ability to metabolize toxicants, leading to variability in toxicity and susceptibility. For example, variations in the CYP2D6 gene can influence how well a person metabolizes certain drugs and environmental chemicals. Poor metabolizers may experience higher toxicity, while ultra-rapid metabolizers may require higher doses for therapeutic efficacy.
