How Do Genetic Variations in Transport Proteins Influence Toxicology?
Genetic polymorphisms in transport proteins can lead to variations in their expression and function, affecting an individual's susceptibility to toxicants. For example, polymorphisms in the ABCB1 gene, which encodes P-gp, can alter the protein's ability to transport toxins, potentially leading to variable responses to drug therapy and environmental exposures. Understanding these genetic differences is crucial for personalized medicine and risk assessment in toxicology.
