How Do Genetic Variations Influence Toxicological Responses?
Genetic variations can significantly affect how individuals respond to toxic substances. Variations in genes coding for metabolic enzymes, transporters, and receptors can alter the efficacy of toxin metabolism and excretion. For example, polymorphisms in the cytochrome P450 family can lead to differences in the metabolic rate of toxins, affecting susceptibility to adverse effects. Understanding these genetic influences is essential for developing personalized approaches in toxicology, such as risk assessments and treatment strategies.
