How Do Scientists Address Uncertainty in Cancer Slope Factors?
To manage uncertainty, scientists employ various approaches, such as using uncertainty factors and conducting sensitivity analyses. Uncertainty factors account for gaps in data and differences between study conditions and real-world scenarios. Sensitivity analyses explore how changes in input variables affect risk estimates, helping identify key contributors to uncertainty. Additionally, the development of biologically-based models and the integration of new scientific findings aid in refining CSFs and improving their accuracy.
