How Do Species Differences Affect Toxicology Studies?
In toxicology research, differences between species are crucial for interpreting study results and extrapolating data to humans. Animal models are often used to assess toxicity, but interspecies differences in metabolism, absorption, and sensitivity must be considered. For example, the glucuronidation pathway is much more efficient in rodents than in humans, which can lead to discrepancies in toxicity assessments.
