How Does ABCB1 Affect Toxicity and Drug Interactions?
The ABCB1 gene influences the toxicity profiles of drugs and their interaction potential. By limiting the accumulation of toxic substances in sensitive tissues, P-glycoprotein plays a protective role. However, this also means that drugs that inhibit or are substrates of P-gp can lead to increased toxicity or altered drug levels when co-administered. Managing these drug interactions is essential in clinical settings to avoid adverse effects.
