age and sex

How does age affect toxicological responses?

Age is a critical factor in toxicology as it influences both the exposure and response to toxic substances. Infants and children are particularly vulnerable due to their developing organs and metabolic systems. Their bodies may not efficiently detoxify and eliminate hazardous substances, leading to higher toxicity. Conversely, the elderly may also be at increased risk due to decreased renal and hepatic function, affecting the metabolism and excretion of toxins. Age-related changes in body composition, such as increased fat and decreased muscle mass, can further affect the distribution of toxicants.

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