How Does Genetic Variability Affect Toxicological Responses?
Genetic variability plays a crucial role in toxicological responses. Variations in genes that encode for enzymes involved in the metabolism of toxicants can lead to differences in how individuals process and eliminate these substances. For instance, polymorphisms in the cytochrome P450 family of enzymes can result in varied metabolic rates, influencing both the intensity and duration of a toxicant's effect. Personalized medicine and pharmacogenomics are increasingly considering these genetic differences to tailor treatments and minimize adverse effects.
