biological makeup

How Does Genetic Variation Affect Toxicology?

Genetic variation among individuals can lead to different responses to the same chemical exposure. Polymorphisms in genes encoding for enzymes involved in the metabolism of toxins can result in variations in the rate of metabolism. For example, differences in cytochrome P450 enzymes can lead to altered drug metabolism, affecting both efficacy and toxicity. This genetic diversity is a key consideration in pharmacogenomics, which aims to tailor drug treatments based on individual genetic profiles.

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