GFR can be measured using creatinine clearance, which involves calculating the rate at which creatinine, a waste product, is cleared from the blood by the kidneys. This involves collecting urine over a 24-hour period and measuring serum creatinine levels. Alternatively, estimated GFR (eGFR) can be calculated using equations that consider age, sex, body size, and serum creatinine levels. These methods are essential for monitoring renal function in patients exposed to nephrotoxic agents.