How Does Genetic Variation Affect Warfarin Metabolism?
Genetic polymorphisms in the CYP2C9 enzyme can significantly affect the metabolism of warfarin. Individuals with certain CYP2C9 variants metabolize warfarin more slowly, requiring lower doses to maintain therapeutic levels. Conversely, those with less common variants may require higher doses, contributing to warfarin resistance. The VKORC1 gene also plays a crucial role, as it encodes the target enzyme inhibited by warfarin. Variations here can affect sensitivity to the drug, necessitating dose adjustments.
