What are the Toxicological Implications of MAO Dysfunction?
Dysfunction of MAO, whether due to genetic mutations or exposure to environmental toxins, can result in neurotoxic effects. For example, polymorphisms in MAO genes have been associated with an increased risk of psychiatric disorders and aggressive behavior. Moreover, exposure to certain industrial chemicals and pesticides has been shown to inhibit MAO activity, leading to the accumulation of toxic monoamines and oxidative stress in the brain.
