ITS benefit regulatory toxicology by enhancing the efficiency and reliability of safety assessments. Regulatory agencies, such as the ECHA and the EPA, are increasingly adopting ITS to streamline the evaluation process. The use of ITS allows for the prioritization of chemicals that pose a higher risk, ensuring that resources are allocated effectively. Furthermore, ITS facilitate the compliance with international guidelines, such as the OECD test guidelines, promoting harmonization across different jurisdictions.