What are the Clinical Implications of PXR Activation?
In clinical settings, PXR activation can have significant implications. The induction of enzymes like CYP3A4 can lead to altered drug efficacy and safety, necessitating dose adjustments. For example, patients on medications metabolized by these enzymes might experience reduced therapeutic effects or increased side effects when concomitantly using PXR activators. Additionally, PXR-mediated drug-drug interactions are a major consideration in polypharmacy, especially in vulnerable populations such as the elderly.
