The microenvironment can influence toxicity in several ways: 1. Chemical Interactions: The presence of other chemicals can lead to synergistic or antagonistic effects, altering the overall toxicity. 2. Cellular Response: Different cell types within a microenvironment may respond differently to the same toxicant. For example, immune cells might react differently than epithelial cells. 3. Metabolic Activity: The local metabolic activity can either enhance or mitigate the effects of a toxicant. Enzymes present in the microenvironment can metabolize toxic substances into more or less harmful compounds.
