NAC works by enhancing the detoxification process. When an individual overdoses on acetaminophen, the liver metabolizes the drug into a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI). Glutathione normally neutralizes NAPQI, but in an overdose situation, glutathione levels become depleted. NAC acts as a precursor to glutathione, thus helping to restore its levels and detoxify NAPQI, preventing liver damage.
