The safe dosage of hyperforin varies depending on several factors, including the individual's health status, age, and concurrent medication use. Generally, products containing St. John's Wort are standardized to contain specific amounts of hyperforin, usually ranging from 0.1% to 5%. It is crucial to follow the manufacturer's guidelines and consult a healthcare professional for personalized advice. Long-term use should be monitored by a healthcare provider due to the potential for cumulative effects and interactions.