When introduced into the bloodstream, phalloidin targets liver cells, causing rapid and irreversible damage. The liver is primarily affected due to its role in detoxification and blood filtration, making it susceptible to toxins. The stabilization of actin filaments by phalloidin leads to impaired cellular processes, eventually resulting in liver failure and potentially death if not treated promptly. However, its inability to cross the intestinal barrier makes it less of a threat through ingestion when compared to other toxins from Amanita phalloides, like amatoxins.
