polymorphism

How Does Polymorphism Affect Drug Metabolism?

Polymorphisms in genes encoding for enzymes involved in drug metabolism, such as the cytochrome P450 family, can significantly alter the pharmacokinetics of drugs. These variations can lead to differences in drug efficacy and toxicity among individuals. For instance, some people may metabolize a drug too quickly, reducing its efficacy, while others may metabolize it too slowly, increasing the risk of adverse effects.

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