While the glycemic index itself is not inherently related to toxicology, it can play a role in understanding how certain substances affect the human body. For instance, high-GI foods can lead to rapid spikes in blood sugar, potentially exacerbating the effects of certain toxins or contributing to the development of conditions that may increase vulnerability to toxic substances. For example, individuals with diabetes or metabolic syndrome, conditions often associated with high-GI diets, may have altered responses to environmental toxins.