The GI tract can be directly affected by toxic substances through ingestion. Once ingested, toxins can irritate the lining of the stomach and intestines, leading to inflammation and increased peristalsis, which often results in vomiting and diarrhea. Some toxins can also be absorbed into the bloodstream, causing systemic effects that manifest as GI symptoms. Additionally, the liver, which processes many toxins, can be overwhelmed, leading to further digestive issues.