How does TPO contribute to thyroid hormone synthesis?
TPO catalyzes the key steps in thyroid hormone production within the thyroid gland. It facilitates the iodination of tyrosine residues on thyroglobulin, producing monoiodotyrosine (MIT) and diiodotyrosine (DIT). Subsequently, TPO catalyzes the coupling of these iodinated residues to form T3 and T4. These hormones are pivotal for regulating metabolism, growth, and development.
