Inhibition of TPO can lead to decreased production of thyroid hormones, resulting in a condition known as hypothyroidism. Symptoms of hypothyroidism include fatigue, weight gain, cold intolerance, and depression. In severe cases, it can cause developmental issues in children and cardiovascular problems in adults. Toxicological studies often examine how various substances, such as certain drugs and environmental chemicals, can inhibit TPO and disrupt endocrine function.
