What are the toxicological concerns associated with DPIs?
While DPIs are generally considered safe, there are some toxicological concerns that need to be considered:
Excipients: DPIs often contain excipients like lactose to aid in the dispersion of the active ingredient. While generally regarded as safe, some individuals may experience allergic reactions or intolerances. Particle Size: The size of the particles in the powder is critical. Particles that are too large may not reach the lungs, while very fine particles could penetrate deep into the alveoli and potentially cause pulmonary toxicity. Device and Usage: Incorrect usage or malfunction of the inhaler device can lead to inadequate dosing, increased local side effects, or systemic toxicity.
