human relevant

How is Human Relevance Assessed?

Assessing human relevance involves several approaches:
Comparative Biology: Evaluating the biological and chemical similarities between test organisms and humans.
Mechanistic Studies: Understanding the mode of action and determining if the same mechanisms are present in humans.
Dosimetry: Comparing dose-response relationships to ensure that the doses used in studies are relevant to potential human exposures.
Human Data: Utilizing epidemiological studies and human clinical data wherever available.

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