What are the Challenges in Determining Human Relevance?
Several challenges exist in ensuring human relevance, including:
Species Differences: Differences in metabolism, physiology, and genetics between humans and test species can lead to varied responses. Extrapolation: Extrapolating data from high-dose animal studies to low-dose human exposures can be complex. Data Gaps: Lack of comprehensive human data can limit understanding of human relevance. Ethical Considerations: Human studies pose ethical challenges and are often limited in scope.
