Diagnosis of hypocortisolism involves a combination of clinical evaluation, laboratory tests, and imaging studies. Clinicians typically assess cortisol levels through blood or urine tests. The ACTH (adrenocorticotropic hormone) stimulation test is a standard diagnostic tool used to assess adrenal gland response. In the context of toxicology, identifying a toxic exposure history is vital for establishing a connection between the toxin and adrenal insufficiency.