How is p38 MAPK Activation Related to Toxic Exposure?
Exposure to toxic substances often results in cellular stress, leading to the activation of stress-responsive pathways like p38 MAPK. For instance, environmental toxins, such as heavy metals and pesticides, can activate the p38 MAPK pathway, contributing to their toxic effects. This activation can lead to the induction of inflammatory cytokines and stress proteins, exacerbating toxic effects and potentially leading to tissue damage.
