What Are the Challenges in Targeting the p38 MAPK Pathway?
Despite its potential, targeting the p38 MAPK pathway presents several challenges. One major issue is the specificity of inhibitors. Since p38 MAPK shares structural similarities with other kinases, achieving selective inhibition without off-target effects is difficult. Moreover, the dual role of p38 MAPK in both promoting and resolving inflammation complicates therapeutic strategies. Long-term inhibition could impair normal cellular functions, highlighting the need for precise modulation rather than complete blockade.
