What Role Does p38 MAPK Play in Mediating Inflammation?
Inflammatory responses are a common consequence of toxicant exposure, and p38 MAPK is a critical mediator in this process. It regulates the production of pro-inflammatory cytokines like TNF-alpha, IL-1, and IL-6. These cytokines contribute to the inflammatory cascade, which, while protective in the short term, can lead to chronic inflammation and tissue damage if unregulated. Therefore, the p38 MAPK pathway is a potential target for anti-inflammatory therapies in conditions induced by toxins.
