How to Determine if a Substance Follows Linear Pharmacokinetics?
To determine if a substance follows linear pharmacokinetics, pharmacokinetic studies can be conducted at different dose levels. If the pharmacokinetic parameters (e.g., clearance, volume of distribution) remain constant across these doses, the substance likely follows a linear model. Additionally, plotting plasma concentration versus time on a semi-logarithmic graph should yield a straight line if the kinetics are linear.
