Cationic amphiphilic drugs (CADs) are a class of compounds characterized by their dual nature, featuring both a hydrophobic and a hydrophilic component. This structural feature allows them to interact with cellular membranes, making them effective in a variety of pharmacological applications. CADs are commonly used in the treatment of conditions such as cardiovascular disease, psychiatric disorders, and infections. However, their ability to integrate into cell membranes raises concerns regarding their toxicological impact.