nk1 receptor antagonists

What are NK1 Receptor Antagonists?

NK1 receptor antagonists are compounds that block the neurokinin 1 (NK1) receptor, which is a G-protein coupled receptor predominantly found in the central and peripheral nervous systems. The NK1 receptor has high affinity for substance P, a neuropeptide involved in pain transmission, inflammation, and the emetic (vomiting) reflex. By inhibiting the interaction between substance P and the NK1 receptor, these antagonists can mitigate various physiological responses.

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