glutathione s transferases

What is the Significance of GST Polymorphisms?

Genetic polymorphisms in GSTs can significantly influence an individual's susceptibility to toxins and the efficacy of certain drugs. Some individuals may possess polymorphic variants of GST genes, leading to altered enzyme activity. These variations can affect drug metabolism, disease risk, and response to environmental toxins. For instance, polymorphisms in GSTM1 and GSTT1 genes have been associated with increased risk of cancer and adverse drug reactions.

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