NK1 receptors, also known as neurokinin-1 receptors, are a type of G protein-coupled receptor that primarily bind to the neuropeptide substance P. These receptors are extensively distributed in the central and peripheral nervous systems and play a pivotal role in mediating various physiological and pathological processes. The activation of NK1 receptors is primarily associated with the transmission of pain signals, regulation of mood, and control of emesis (vomiting).
