Implementing TSCA presents several challenges, including the vast number of chemicals present in commerce and the complexity of assessing their risks. The lack of data on many chemicals makes it difficult to determine their safety. Additionally, balancing the need for chemical innovation with public health protection can be challenging. Toxicologists often face difficulties in evaluating complex mixtures and understanding the long-term impacts of low-dose exposures. Another challenge is the need for improved testing methods that minimize animal use, aligning with the principles of 3Rs (Replacement, Reduction, and Refinement) in toxicology.
