In Vitro Testing In vitro testing involves studying cells or biological molecules outside their normal biological context, usually in a petri dish or test tube. Examples include cell culture assays and high-throughput screening techniques. These methods can help determine cytotoxicity, genotoxicity, and other toxicological endpoints.
Computational Models Computational models or in silico methods use computer simulations to predict the toxicity of substances. These models can analyze large datasets to identify patterns and predict outcomes, providing valuable insights without the need for physical testing. Examples include Quantitative Structure-Activity Relationship (QSAR) models and molecular docking studies.
Organ-on-a-Chip Technology Organ-on-a-chip technology involves microfluidic devices that simulate the activities, mechanics, and physiological responses of entire organs and organ systems. These chips can mimic the human organs' environment more accurately than traditional in vitro methods, providing more relevant data for human health risk assessments.
