What are the advantages and limitations of in vivo models?
In vivo models offer a comprehensive understanding of how a toxicant affects an entire organism, capturing complex interactions that cannot be observed in vitro. They are essential for risk assessment, as they provide data on ADME properties and potential systemic effects. However, in vivo models are ethically contentious, expensive, and time-consuming. Differences between species can also limit the extrapolation of results to humans, posing challenges in predicting human toxicity accurately.
