In vivo imaging offers several advantages in toxicological studies:
- Non-Invasive Monitoring: It allows for the continuous observation of biological processes without the need for invasive procedures, reducing the stress and harm to the test subjects.
- Longitudinal Studies: Researchers can track the progression of toxic effects over time, providing a comprehensive understanding of the toxicity profile of a substance.
- Reduced Sample Size: By visualizing changes in the same subject over time, fewer animals are required, aligning with the principles of the 3Rs (Replacement, Reduction, and Refinement) in animal research.
- Early Detection: In vivo imaging can identify early biomarkers of toxicity, facilitating the prediction of adverse effects before they manifest clinically.
